Title : The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

Pub. Date : 2005 May 13

PMID : 15753082






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In a human tumor cell line with high MKP-1 levels, sanguinarine caused enhanced ERK and JNK/SAPK phosphorylation. sanguinarine mitogen-activated protein kinase 1 Homo sapiens
2 A close congener of sanguinarine, chelerythrine, also inhibited MKP-1 in vitro and in whole cells, and activated ERK and JNK/SAPK. sanguinarine mitogen-activated protein kinase 1 Homo sapiens