Pub. Date : 2005 Jun
PMID : 15749994
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides. | Quercetin | ATP binding cassette subfamily G member 2 | Rattus norvegicus |
| 2 | Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides. | Quercetin | ATP binding cassette subfamily G member 2 | Rattus norvegicus |
| 3 | When intestinal Bcrp1 was inhibited by FTC in Mrp2-deficient rats, total plasma concentrations of quercetin and its methylated metabolite isorhamnetin after 30 min of perfusion were more than twice that of controls (12.3 +/- 1.5 versus 5.6 +/- 1.3 muM; p < 0.01), whereas uptake of free quercetin from the intestinal lumen was not affected. | Quercetin | ATP binding cassette subfamily G member 2 | Rattus norvegicus |
| 4 | When intestinal Bcrp1 was inhibited by FTC in Mrp2-deficient rats, total plasma concentrations of quercetin and its methylated metabolite isorhamnetin after 30 min of perfusion were more than twice that of controls (12.3 +/- 1.5 versus 5.6 +/- 1.3 muM; p < 0.01), whereas uptake of free quercetin from the intestinal lumen was not affected. | Quercetin | ATP binding cassette subfamily G member 2 | Rattus norvegicus |
| 5 | In conclusion, Bcrp1 limits net intestinal absorption of quercetin by pumping quercetin glucuronides back into the lumen. | Quercetin | ATP binding cassette subfamily G member 2 | Rattus norvegicus |