Title : Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production.

Pub. Date : 2005

PMID : 15743480






2 Functional Relationships(s)
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1 Similarly, the ET-1-induced NO production was partially suppressed by the p38 kinase inhibitor and was completely suppressed by the protein kinase A kinase inhibitor KT5720 and by LY83583, suggesting the involvement of these enzymes in relevant ET-1 signalling pathways. KT 5720 endothelin 1 Homo sapiens
2 Similarly, the ET-1-induced NO production was partially suppressed by the p38 kinase inhibitor and was completely suppressed by the protein kinase A kinase inhibitor KT5720 and by LY83583, suggesting the involvement of these enzymes in relevant ET-1 signalling pathways. KT 5720 endothelin 1 Homo sapiens