Pub. Date : 2004 Sep
PMID : 15742978
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In human liver microsomes, the (S)-7-hydroxylation--being the major metabolic pathway--was significantly compromised in a gene-dose-dependent manner in samples expressing the CYP2C9*2 or CYP2C9*3 allele. | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | In human liver microsomes, the (S)-7-hydroxylation--being the major metabolic pathway--was significantly compromised in a gene-dose-dependent manner in samples expressing the CYP2C9*2 or CYP2C9*3 allele. | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | The CYP2C9*3/*3 genotype corresponded to an almost fourfold lower (S)-7-hydroxylation rate than CYP2C9*1/*1 (wild-type). | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | The intrinsic clearance of human recombinant CYP2C9*2 and CYP2C9*3 for the (S)-7-hydroxylation was 28.9 and 50.9% lower than of CYP2C9*1, respectively. | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 5 | The intrinsic clearance of human recombinant CYP2C9*2 and CYP2C9*3 for the (S)-7-hydroxylation was 28.9 and 50.9% lower than of CYP2C9*1, respectively. | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 6 | The intrinsic clearance of human recombinant CYP2C9*2 and CYP2C9*3 for the (S)-7-hydroxylation was 28.9 and 50.9% lower than of CYP2C9*1, respectively. | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 7 | Increasing plasma AUC metabolic ratios (parent compound/metabolite) in CYP2C9*2 and CYP2C9*3 variant allele carriers were found for each hydroxylation reaction and the CYP2C9*3/*3 genotype corresponded to an about 10-fold higher metabolic ratio of PPC (S)-7-hydroxylation relative to CYP2C9*1/*1. | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 8 | Increasing plasma AUC metabolic ratios (parent compound/metabolite) in CYP2C9*2 and CYP2C9*3 variant allele carriers were found for each hydroxylation reaction and the CYP2C9*3/*3 genotype corresponded to an about 10-fold higher metabolic ratio of PPC (S)-7-hydroxylation relative to CYP2C9*1/*1. | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 9 | Increasing plasma AUC metabolic ratios (parent compound/metabolite) in CYP2C9*2 and CYP2C9*3 variant allele carriers were found for each hydroxylation reaction and the CYP2C9*3/*3 genotype corresponded to an about 10-fold higher metabolic ratio of PPC (S)-7-hydroxylation relative to CYP2C9*1/*1. | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 10 | Increasing plasma AUC metabolic ratios (parent compound/metabolite) in CYP2C9*2 and CYP2C9*3 variant allele carriers were found for each hydroxylation reaction and the CYP2C9*3/*3 genotype corresponded to an about 10-fold higher metabolic ratio of PPC (S)-7-hydroxylation relative to CYP2C9*1/*1. | Sulfur | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |