Pub. Date : 1977 May
PMID : 15737
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of beta-blocking agents and angiotensin II on isoproterenol-stimulated renin release from rat kidney slices. | Isoproterenol | renin | Rattus norvegicus |
| 2 | We previously demonstrated that renin release by kidney slices may be increased by beta-adrenergic agonists, and the present communication contains our results on the effects of 15 beta-blocking agents and angiotensin II on isoproterenol-stimulated renin release. | Isoproterenol | renin | Rattus norvegicus |
| 3 | We previously demonstrated that renin release by kidney slices may be increased by beta-adrenergic agonists, and the present communication contains our results on the effects of 15 beta-blocking agents and angiotensin II on isoproterenol-stimulated renin release. | Isoproterenol | renin | Rattus norvegicus |
| 4 | (3) Dose-related inhibition was observed with practolol, oxprenolol, timolol, nadolol, and atenolol at concentrations ranging from 10-8 to 10-5 m. Basal renin release was significantly (P is less than 0.01) inhibited by angiotensin II at 10-6 m, which also inhibited isoproterenol-stimulated renin release in a dose-related fashion. | Isoproterenol | renin | Rattus norvegicus |
| 5 | CONCLUSIONS: There are three different effects of beta-blocking agents on isoproterenol-stimulated renin release which can only partially be explained by their presently ascribed pharmacological properties. | Isoproterenol | renin | Rattus norvegicus |