Title : Improvement of the specificity of dipetarudin by site directed mutagenesis.

Pub. Date : 2005 Mar

PMID : 15735791






1 Functional Relationships(s)
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1 Due to the specificity of an inhibitor being influenced by the amino acid residue at the P1 position, we replaced the Arg10 at P1 position of dipetarudin by a histidine, which is the P1 residue of rhodniin, a very specific thrombin inhibitor. Histidine coagulation factor II, thrombin Homo sapiens