Title : Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression.

Pub. Date : 2005 Mar

PMID : 15735612






3 Functional Relationships(s)
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1 Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression. Clarithromycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 This study was designed to identify determinants of variability in the extent of intestinal wall CYP3A inhibition by clarithromycin, such as CYP3A5 genotype, and the mechanism of inhibition. Clarithromycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 CONCLUSION: Baseline intestinal activity of CYP3A4 was a key determinant of variability of the inhibitory effect of clarithromycin among individuals. Clarithromycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens