Pub. Date : 2005 Mar
PMID : 15735102
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Phosphorylation of the mitogen-activated protein (MAP) kinases, c-jun N-terminal (JNK)1,2 and p38, was also increased by the combination of ellagic acid and quercetin, whereas quercetin alone induced only p38. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |
2 | Phosphorylation of the mitogen-activated protein (MAP) kinases, c-jun N-terminal (JNK)1,2 and p38, was also increased by the combination of ellagic acid and quercetin, whereas quercetin alone induced only p38. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |
3 | In summary, quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1) and the MAP kinases, JNK1,2 and p38, in a more than additive manner, suggesting a mechanism by which quercetin and ellagic acid synergistically induce apoptosis in cancer cells. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |