Pub. Date : 2005 Mar
PMID : 15731592
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alfentanil undergoes extensive metabolism by cytochrome P4503A4 (CYP3A4). | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Alfentanil undergoes extensive metabolism by cytochrome P4503A4 (CYP3A4). | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | METHODS: Alfentanil metabolism to noralfentanil and N-phenylpropionamide was determined in microsomes from two groups of human livers, characterized for CYP3A4 and CYP3A5 protein content: low CYP3A5 (2.0-5.2% of total CYP3A, n = 10) and high CYP3A5 (46-76% of total CYP3A, n = 10). | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The effects of the CYP3A inhibitors troleandomycin and ketoconazole, the latter being more potent toward CYP3A4, on alfentanil metabolism were also determined. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Therefore, alfentanil is metabolized by human liver microsomal CYP3A5 in addition to CYP3A4, and pharmacogenetic variability in CYP3A5 expression significantly influences human liver alfentanil metabolism in vitro. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |