Title : Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin.

Pub. Date : 2005 Jul 20

PMID : 15729714






2 Functional Relationships(s)
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1 On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells. Tetradecanoylphorbol Acetate glucose-6-phosphate isomerase Homo sapiens
2 On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells. Tetradecanoylphorbol Acetate glucose-6-phosphate isomerase Homo sapiens