Title : Hepatic uptake of the novel antifungal agent caspofungin.

Pub. Date : 2005 May

PMID : 15716364






3 Functional Relationships(s)
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1 To identify a relevant hepatic uptake transporter, we developed novel Tet-on HeLa cells expressing OATP1B1 (OATP-C, SLC21A6) and OATP1B3 (OATP8, SLC21A8), whose target gene can be overexpressed by the addition of doxycycline. tetramethylenedisulfotetramine solute carrier organic anion transporter family member 1B1 Homo sapiens
2 To identify a relevant hepatic uptake transporter, we developed novel Tet-on HeLa cells expressing OATP1B1 (OATP-C, SLC21A6) and OATP1B3 (OATP8, SLC21A8), whose target gene can be overexpressed by the addition of doxycycline. tetramethylenedisulfotetramine solute carrier organic anion transporter family member 1B1 Homo sapiens
3 To identify a relevant hepatic uptake transporter, we developed novel Tet-on HeLa cells expressing OATP1B1 (OATP-C, SLC21A6) and OATP1B3 (OATP8, SLC21A8), whose target gene can be overexpressed by the addition of doxycycline. tetramethylenedisulfotetramine solute carrier organic anion transporter family member 1B1 Homo sapiens