Title : Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model.

Pub. Date : 2005 Feb 22

PMID : 15709769






2 Functional Relationships(s)
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1 Herein we have examined in detail the catalyzed GDP/GTP exchange reaction mechanism by a Ras specific GEF, GRF1. Guanosine Diphosphate Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens
2 Furthermore, we found that Ras was capable of binding pyrophosphate (PPi) with a dissociation constant of 26 microM and that PPi and GMP, but neither alone, synergistically potentiated the GRF1-stimulated GDP dissociation from Ras. Guanosine Diphosphate Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens