Pub. Date : 2005 Mar
PMID : 15702236
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin-induced suppression of glucose-6-phosphatase expression is independent of insulin signaling in rat hepatoma cells. | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |
| 2 | To elucidate the pharmacological action of metformin on hepatic glucose production, we examined its effect on the gene expression of glucose-6-phosphatase (G6Pase), a key enzyme of gluconeogenesis, in H4IIE rat hepatoma cell line by RT-PCR and quantitative real-time PCR. | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |
| 3 | To elucidate the pharmacological action of metformin on hepatic glucose production, we examined its effect on the gene expression of glucose-6-phosphatase (G6Pase), a key enzyme of gluconeogenesis, in H4IIE rat hepatoma cell line by RT-PCR and quantitative real-time PCR. | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |
| 4 | Metformin suppressed dexamethasone/cAMP-induced expression of G6Pase mRNA in a dose dependent manner, its maximum effect being observed at 2 mM (79.3% inhibition, P<0.05). | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |
| 5 | In the present study, we demonstrate that metformin suppresses G6Pase mRNA expression by a mechanism that is independent of the activation of PI3-kinase, Akt, MAP kinase and protein kinase C pathway in hepatocytes. | Metformin | glucose-6-phosphatase catalytic subunit 1 | Rattus norvegicus |