Title : Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction.

Pub. Date : 2005 Feb 16

PMID : 15701008

1 Functional Relationships(s)
Compound Name
Protein Name
1 Based on these structures, synthesis of second generation LacNAc derivatives carrying aromatic amides at 3"-C, followed by screening with a novel fluorescence polarization assay, has led to the identification of inhibitors with further enhanced affinity for galectin-3 (K(d) > or = 320 nM). N-acetyllactosamine galectin 3 Homo sapiens