Pub. Date : 2005 Feb 8
PMID : 15694923
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits. | Galantamine | acetylcholinesterase | Rattus norvegicus |
| 2 | Galantamine is a rather weak acetylcholinesterase (AChE) inhibitor, currently approved for the symptomatic treatment of Alzheimer"s disease, with possible additional allosteric potentiating effects at the nicotinic ACh receptor (nAChR). | Galantamine | acetylcholinesterase | Rattus norvegicus |
| 3 | Galantamine is a rather weak acetylcholinesterase (AChE) inhibitor, currently approved for the symptomatic treatment of Alzheimer"s disease, with possible additional allosteric potentiating effects at the nicotinic ACh receptor (nAChR). | Galantamine | acetylcholinesterase | Rattus norvegicus |
| 4 | Earlier data from in vitro biochemical tests suggest that donepezil is 40- to 500-fold more potent than galantamine in inhibiting AChE. | Galantamine | acetylcholinesterase | Rattus norvegicus |
| 5 | In this study, both brain levels and Ki values for AChE inhibition for donepezil and galantamine in rat, mouse, and rabbit after subcutaneous application were determined. | Galantamine | acetylcholinesterase | Rattus norvegicus |
| 6 | Ki values of brain AChE inhibition for galantamine and donepezil, respectively, are 7.1 and 2.3 microg/g in rats, 8.3 and 0.65 microg/g for mice, and 19.1 and 1.3 microg/g in rabbits. | Galantamine | acetylcholinesterase | Rattus norvegicus |
| 7 | The data also suggest that for a similar degree of brain AChE inhibition, 3-15 times higher galantamine than donepezil doses are needed. | Galantamine | acetylcholinesterase | Rattus norvegicus |