Title : Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway.

Pub. Date : 2005 May

PMID : 15684043

1 Functional Relationships(s)
Compound Name
Protein Name
1 In this study, by using a murine model of inflammation, the carrageenin-induced paw edema in mouse, we show that the anti-inflammatory activity exhibited by the PPAR-gamma agonists rosiglitazone and ciglitazone is reversed by the GR antagonist RU486 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl]-17 alpha-[1-propynyl]estra-4,9-dien-3-one). ciglitazone peroxisome proliferator activated receptor gamma Mus musculus