Title : Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.

Pub. Date : 2005 Feb

PMID : 15681865






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The conformation of mDHFR Arg22 is such that it makes hydrogen-bonding contacts with Asp21, Trp24 and a structural water molecule, observations which were not made in the L22R hDHFR ternary complex. Hydrogen beta-secretase 2 Homo sapiens