Title : In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases.

Pub. Date : 2005 Jun

PMID : 15681398






1 Functional Relationships(s)
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1 In vitro experiments showed that inhibition of endogenous serine proteases by apical aprotinin 1) decreased ENaC-mediated currents in primary cultures of rat and mouse alveolar epithelial cells without affecting the abundance nor the electrophoretic migration pattern of biotinylated alpha- and beta-ENaC expressed at the cell surface and 2) suppressed the increase in amiloride-sensitive short-circuit current induced by the beta2-agonist terbutaline. Amiloride sodium channel epithelial 1 subunit gamma Rattus norvegicus