Title : Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures.

Pub. Date : 2005 Jan 25

PMID : 15670336






1 Functional Relationships(s)
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1 RESULTS: Rat microglial cells express alpha7 nicotinic receptor, and its activation by nicotine dose-dependently reduces the LPS-induced release of TNF-alpha, but has little or no effect on nitric oxide, interleukin-10 and interleukin-1beta. Nicotine tumor necrosis factor Rattus norvegicus