Pub. Date : 2005 Jan
PMID : 15665861
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNFalpha attenuated SP- and NKA-induced relaxation in a time- and concentration-dependent manner, decreasing the ability of PGE(2) to relax tissues. | Prostaglandins E | tumor necrosis factor | Mus musculus |
| 2 | Further studies indicated that TNFalpha elevated COX-2 activity and that concomitant inhibition of COX-2 reversed TNFalpha-attenuated PGE(2) relaxation. | Prostaglandins E | tumor necrosis factor | Mus musculus |
| 3 | Overall, these results show that NK(1) receptor-mediated relaxation induced by PGE(2) is attenuated by prolonged TNFalpha stimulation. | Prostaglandins E | tumor necrosis factor | Mus musculus |