Pub. Date : 2005 Apr
PMID : 15665133
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of phospholipase Cbeta (PLCbeta) by G-proteins results in increased intracellular Ca(2+) and activation of protein kinase C. We have previously found that activated PLCbeta-Gbetagamma complex can be rapidly deactivated by Galpha(GDP) subunits without dissociation, which led to the suggestion that Galpha(GDP) binds to PLCbeta-Gbeta gamma and perturbs the activating interaction without significantly affecting the PLCbeta-Gbeta gamma binding energy. | Guanosine Diphosphate | succinate-CoA ligase GDP/ADP-forming subunit alpha | Homo sapiens |
| 2 | In the presence of Galpha(s)(GDP), the volume change associated with PLCbeta-Gbeta gamma interaction is reduced to 25 +/- 1 ml/mol. | Guanosine Diphosphate | succinate-CoA ligase GDP/ADP-forming subunit alpha | Homo sapiens |