Pub. Date : 2005 Feb 21
PMID : 15663961
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 2 | In the present study, we explored protective effect of IL-6 that was chronically applied to cerebellar granule neurons (CGNs) in culture against neurodamage induced by glutamate and mechanisms involved in the neuroprotective effect of IL-6. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 3 | The chronic IL-6 exposure significantly prevented the CGNs from the glutamate-induced attenuation of neuronal vitality. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 4 | The glutamate-evoked neuronal apoptosis also was strikingly inhibited by the chronic IL-6 pretreatment. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 5 | Although intracellular Ca2+ in the IL-6-pretreated CGNs also produced an acute and transient elevation in response to the glutamate insult, they quickly dropped and recovered to basal levels before the glutamate application. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 6 | Although intracellular Ca2+ in the IL-6-pretreated CGNs also produced an acute and transient elevation in response to the glutamate insult, they quickly dropped and recovered to basal levels before the glutamate application. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 7 | Anti-gp130 monoclonal antibody (mAb) blocked the suppressive effect of IL-6 on the glutamate-induced intracellular Ca2+ overload. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 8 | These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 9 | These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 10 | These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. | Glutamic Acid | interleukin 6 | Homo sapiens |
| 11 | These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. | Glutamic Acid | interleukin 6 | Homo sapiens |