Title : 5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells.

Pub. Date : 2005 Apr

PMID : 15661813






2 Functional Relationships(s)
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1 The objective of this study was to examine the ability of dietary polyphenols to inhibit cytochrome P450 (CYP) 1A1 expression and activity and benzo[a]pyrene (BaP) DNA binding, with the main emphasis on prevention of chemical-induced hepatic carcinogenesis. Polyphenols cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 Second, we screened 25 polyphenols with highly varying chemical structures for maximum ability to inhibit CYP1A1 activity in the Hep G2 cells. Polyphenols cytochrome P450 family 1 subfamily A member 1 Homo sapiens