Title : P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway.

Pub. Date : 2005 Jan

PMID : 15661399






5 Functional Relationships(s)
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Protein Name
Organism
1 P-glycoprotein (p-gp) might augment ceramide glycosylation by translocating glucosylceramide (GC) across the Golgi membrane. Glucosylceramides ATP binding cassette subfamily B member 1 Homo sapiens
2 P-glycoprotein (p-gp) might augment ceramide glycosylation by translocating glucosylceramide (GC) across the Golgi membrane. Glucosylceramides ATP binding cassette subfamily B member 1 Homo sapiens
3 P-glycoprotein (p-gp) might augment ceramide glycosylation by translocating glucosylceramide (GC) across the Golgi membrane. Glucosylceramides ATP binding cassette subfamily B member 1 Homo sapiens
4 P-glycoprotein (p-gp) might augment ceramide glycosylation by translocating glucosylceramide (GC) across the Golgi membrane. Glucosylceramides ATP binding cassette subfamily B member 1 Homo sapiens
5 CONCLUSION: Our data suggests that ceramide induces apoptosis in AML cells and that p-gp confers resistance to ceramide-induced apoptosis, with modulation of the ceramide-glucosylceramide pathway making a marked contribution to this resistance in TF-1 cells. Glucosylceramides ATP binding cassette subfamily B member 1 Homo sapiens