Title : AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway.

Pub. Date : 2005 Feb

PMID : 15659221






1 Functional Relationships(s)
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1 However, we found evidence suggesting that AG490 reduces oxidative stress induced by H(2)O(2), which further shows that H(2)O(2) and/or derived reactive oxygen species directly activate Jak2/Stat1, but masks the actual involvement of this pathway in H(2)O(2)-induced cell death. Reactive Oxygen Species Janus kinase 2 Rattus norvegicus