Title : Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates.

Pub. Date : 2005

PMID : 15652995






5 Functional Relationships(s)
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1 Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. Modafinil hypocretin Mus musculus
2 Fos protein immunohistochemistry has previously demonstrated that orexin neurons are activated after modafinil administration, and it has been hypothesized that the wakefulness-promoting properties of modafinil might therefore be mediated by the neuropeptide. Modafinil hypocretin Mus musculus
3 Fos protein immunohistochemistry has previously demonstrated that orexin neurons are activated after modafinil administration, and it has been hypothesized that the wakefulness-promoting properties of modafinil might therefore be mediated by the neuropeptide. Modafinil hypocretin Mus musculus
4 Surprisingly, modafinil more effectively increased wakefulness time in orexin-/- mice than in the wild-type mice. Modafinil hypocretin Mus musculus
5 Modafinil administration only partly compensated for this attention deficit in the orexin null mice. Modafinil hypocretin Mus musculus