Pub. Date : 2005 Mar 18
PMID : 15640525
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thrombin-induced rapid geranylgeranylation was inhibited by acute short term (3 min) pretreatment with atorvastatin as well as by an inhibitor of GGTase I (GGTI-286). | Atorvastatin | coagulation factor II, thrombin | Homo sapiens |
| 2 | Thrombin also rapidly stimulated GTP loading of RhoA, which was blocked by acute pretreatment with either atorvastatin or GGTI-286. | Atorvastatin | coagulation factor II, thrombin | Homo sapiens |
| 3 | Importantly, the addition of geranylgeranylpyrophosphate to ECs pretreated with atorvastatin quickly reversed the atorvastatin inhibition of thrombin stimulation of RhoA. | Atorvastatin | coagulation factor II, thrombin | Homo sapiens |
| 4 | Importantly, the addition of geranylgeranylpyrophosphate to ECs pretreated with atorvastatin quickly reversed the atorvastatin inhibition of thrombin stimulation of RhoA. | Atorvastatin | coagulation factor II, thrombin | Homo sapiens |
| 5 | Cytoskeleton analysis demonstrated that atorvastatin and GGTI-286 inhibited thrombin-induced stress fiber formation. | Atorvastatin | coagulation factor II, thrombin | Homo sapiens |