Pub. Date : 2005 Mar 11
PMID : 15632134
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intracellular phosphorylation analysis showed that phosphorylated PKCalpha and other kinases were lower in wild-type mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) as compared with PPARbeta-null mouse skin. | Tetradecanoylphorbol Acetate | peroxisome proliferator activator receptor delta | Mus musculus |
| 2 | Intracellular phosphorylation analysis showed that phosphorylated PKCalpha and other kinases were lower in wild-type mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) as compared with PPARbeta-null mouse skin. | Tetradecanoylphorbol Acetate | peroxisome proliferator activator receptor delta | Mus musculus |
| 3 | Lower ubiquitination of PKCalpha was found in TPA-treated PPARbeta-null skin as compared with wild-type, and inhibition of ubiquitin-dependent proteasome degradation prevented TPA-induced down-regulation of PKCalpha. | Tetradecanoylphorbol Acetate | peroxisome proliferator activator receptor delta | Mus musculus |
| 4 | Lower ubiquitination of PKCalpha was found in TPA-treated PPARbeta-null skin as compared with wild-type, and inhibition of ubiquitin-dependent proteasome degradation prevented TPA-induced down-regulation of PKCalpha. | Tetradecanoylphorbol Acetate | peroxisome proliferator activator receptor delta | Mus musculus |
| 5 | The activity of PKCalpha and downstream signaling kinases is enhanced, and expression of cyclooxygenase-2 (COX-2) is significantly greater, in PPARbeta-null mouse skin in response to TPA compared with wild-type mouse skin. | Tetradecanoylphorbol Acetate | peroxisome proliferator activator receptor delta | Mus musculus |
| 6 | Inhibition of PKCalpha or COX-2 reduced cell proliferation in TPA-treated PPARbeta-null keratinocytes in a dose-dependent manner, whereas it only slightly influenced cell proliferation in wild-type keratinocytes. | Tetradecanoylphorbol Acetate | peroxisome proliferator activator receptor delta | Mus musculus |