Title : Use of 11alpha-deuterium labeled cortisol as a tracer for assessing reduced 11beta-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject.

Pub. Date : 2005 Feb

PMID : 15631868






3 Functional Relationships(s)
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1 The kinetic analysis associated with the loss of 11alpha-2H during the conversion of cortisol-13C4,2H1 to cortisone-13C4 by 11beta-HSD2 clearly indicated reduced 11beta-HSD2 activity with glycyrrhetinic acid ingestion, as observed by an increase in the elimination half-life of cortisol-13C4,2H1. Glycyrrhetinic Acid hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens
2 The kinetic analysis associated with the loss of 11alpha-2H during the conversion of cortisol-13C4,2H1 to cortisone-13C4 by 11beta-HSD2 clearly indicated reduced 11beta-HSD2 activity with glycyrrhetinic acid ingestion, as observed by an increase in the elimination half-life of cortisol-13C4,2H1. Glycyrrhetinic Acid hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens
3 The 2H-labeling in the 11alpha-position of cortisol served as an appropriate tracer for assessing the reduced 11beta-HSD2 activity in vivo induced by glycyrrhetinic acid. Glycyrrhetinic Acid hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens