Title : n-3 PUFAs modulate T-cell activation via protein kinase C-alpha and -epsilon and the NF-kappaB signaling pathway.

Pub. Date : 2005 Apr

PMID : 15627650






2 Functional Relationships(s)
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1 Furthermore, two isoforms of phospholipase A(2) (i.e., calcium-dependent and calcium-independent) were implicated in the release of DHA and EPA, respectively, during activation of these cells. Docosahexaenoic Acids phospholipase A2 group IB Homo sapiens
2 Together, these results demonstrate that DHA and EPA, being released by two isoforms of phospholipase A(2), modulate IL-2 gene expression by exerting their action on two PKC isoforms and NF-kappaB in Jurkat T-cells. Docosahexaenoic Acids phospholipase A2 group IB Homo sapiens