Title : P-glycoprotein potentiates CYP3A4-mediated drug disappearance during Caco-2 intestinal secretory detoxification.

Pub. Date : 2004

PMID : 15621665






2 Functional Relationships(s)
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1 In the presence of digoxin, secretory transport of vinblastine and erythromycin, substrates for both Pgp and cytochrome P450 3A4 (CYP3A4), was significantly reduced, whereas absorptive transport was unaffected. Vinblastine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In the presence of digoxin, secretory transport of vinblastine and erythromycin, substrates for both Pgp and cytochrome P450 3A4 (CYP3A4), was significantly reduced, whereas absorptive transport was unaffected. Vinblastine cytochrome P450 family 3 subfamily A member 4 Homo sapiens