Title : Fibrinogen Mannheim II: a novel gamma307 His-->Tyr substitution in the gammaD domain causes hypofibrinogenemia.

Pub. Date : 2004 Dec

PMID : 15613026






2 Functional Relationships(s)
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1 This novel His-->Tyr substitution was not detected when plasma fibrinogen was analyzed by electrospray ionization mass spectrometry. Histidine fibrinogen beta chain Homo sapiens
2 However, the histidine residue appears critical in maintaining structure of the fibrinogen gammaD domain, rather than in determining function. Histidine fibrinogen beta chain Homo sapiens