Title : Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.

Pub. Date : 2005 Mar

PMID : 15604518






3 Functional Relationships(s)
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1 Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. Cholesterol peroxisome proliferator activator receptor delta Mus musculus
2 Activation of PPARdelta may have antiatherogenic effects through the increase of plasma HDL, theoretically promoting reverse cholesterol transport from peripheral tissues toward the liver for removal via bile and feces. Cholesterol peroxisome proliferator activator receptor delta Mus musculus
3 PPARdelta activation is associated with increased plasma HDL and reduced intestinal cholesterol absorption efficiency that may be related to decreased intestinal Npc1l1 expression. Cholesterol peroxisome proliferator activator receptor delta Mus musculus