Pub. Date : 2005 Jan
PMID : 15601808
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Alfentanil is a selective CYP3A probe but not a P-gp substrate. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | This investigation tested the hypothesis that alfentanil and fexofenadine could be administered in combination to probe first-pass CYP3A and P-gp activities in humans. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Alfentanil and fexofenadine in combination appear to be a useful probe for evaluating both first-pass CYP3A and P-gp activities in humans. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |