Title : Interleukin-6 increases rat metalloproteinase-13 gene expression through Janus kinase-2-mediated inhibition of serine/threonine phosphatase-2A.

Pub. Date : 2005 Apr

PMID : 15601621






1 Functional Relationships(s)
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1 We conclude that IL-6 increases MMP-13 gene expression by activation of Jak2, resulting in tyrosine phosphorylation of the catalytic subunit of PP2A, which in turn decreases PP2A activity and prolongs c-Jun phosphorylation. Tyrosine Janus kinase 2 Rattus norvegicus