Title : FK506 suppresses E-selectin, ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor necrosis factor alpha secretion from peripheral blood mononuclear cells.

Pub. Date : 2005 Jan 21

PMID : 15598440






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 FK506 suppresses E-selectin, ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor necrosis factor alpha secretion from peripheral blood mononuclear cells. Tacrolimus vascular cell adhesion molecule 1 Homo sapiens
2 FK506 suppresses activation of T cells; however, it down-regulates E-selectin, ICAM-1 and VCAM-1 expression in inflamed tissues. Tacrolimus vascular cell adhesion molecule 1 Homo sapiens
3 Culture supernatant from peripheral blood mononuclear cells (PBMC) stimulated with anti-CD3 plus anti-CD2 antibodies effectively induced the expression of E-selectin, ICAM-1 and VCAM-1 on HMVEC, and treatment with FK506 down-regulated their expression. Tacrolimus vascular cell adhesion molecule 1 Homo sapiens