Title : gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis.

Pub. Date : 2004 Dec 21

PMID : 15596715






1 Functional Relationships(s)
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1 Myriocin and fumonisin B1, specific inhibitors of key enzymes (serine palmitoyltransferase and dihydroceramide synthase, respectively) in de novo synthesis of sphingolipids, significantly protected cells from gammaT-induced DNA fragmentation, cytochrome c release, PARP cleavage, and the formation of active caspase 3. thermozymocidin poly(ADP-ribose) polymerase 1 Homo sapiens