Title : ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts.

Pub. Date : 2005 Jan 14

PMID : 15582581






1 Functional Relationships(s)
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1 Over the same concentration range of the nucleotide that was effective for IL-6 synthesis, ATP caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which increase was inhibited by pretreatment with suramin, a P2Y receptor antagonist, or 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate receptor blocker, but not by the extracellular Ca(2+)-chelating agent EGTA. Egtazic Acid interleukin 6 Homo sapiens