Title : Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy.

Pub. Date : 2004 Nov

PMID : 15582027






5 Functional Relationships(s)
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1 The succinic semialdehyde dehydrogenase (SSADH) null mouse represents a viable animal model for human SSADH deficiency and is characterized by markedly elevated levels of both gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acid (GABA) in brain, blood, and urine. 4-hydroxybutyric acid aldhehyde dehydrogenase family 5, subfamily A1 Mus musculus
2 The succinic semialdehyde dehydrogenase (SSADH) null mouse represents a viable animal model for human SSADH deficiency and is characterized by markedly elevated levels of both gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acid (GABA) in brain, blood, and urine. 4-hydroxybutyric acid aldhehyde dehydrogenase family 5, subfamily A1 Mus musculus
3 The succinic semialdehyde dehydrogenase (SSADH) null mouse represents a viable animal model for human SSADH deficiency and is characterized by markedly elevated levels of both gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acid (GABA) in brain, blood, and urine. 4-hydroxybutyric acid aldhehyde dehydrogenase family 5, subfamily A1 Mus musculus
4 The succinic semialdehyde dehydrogenase (SSADH) null mouse represents a viable animal model for human SSADH deficiency and is characterized by markedly elevated levels of both gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acid (GABA) in brain, blood, and urine. 4-hydroxybutyric acid aldhehyde dehydrogenase family 5, subfamily A1 Mus musculus
5 We tested the hypothesis that the phenotype of the SSADH(-/-) mouse shows absence-like seizures because of the inordinately high levels of GHB in the brain of this mutant animal. 4-hydroxybutyric acid aldhehyde dehydrogenase family 5, subfamily A1 Mus musculus