Title : Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.

Pub. Date : 2004 Dec 14

PMID : 15581350






1 Functional Relationships(s)
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1 Twenty CYP2C8 site-directed mutants were constructed and expressed in yeast to compare their catalytic activities using five CYP2C8 substrates that exhibit different structures and sizes [paclitaxel, fluvastatin, retinoic acid, a sulfaphenazole derivative (DMZ), and diclofenac]. Sulfaphenazole cytochrome P450 family 2 subfamily C member 8 Homo sapiens