Title : Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley rats.

Pub. Date : 2004 Nov

PMID : 15581186






1 Functional Relationships(s)
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1 Western blot analyses demonstrated that MNU exposure caused progressive reduction of p21 protein levels, an increase of Rb phosphorylation, activation of AKT and CDK2, and upregulation of FGF receptors. Methylnitrosourea KRAS proto-oncogene, GTPase Rattus norvegicus