Title : Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL.

Pub. Date : 2005 Feb

PMID : 15576844






3 Functional Relationships(s)
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1 Although total postheparin plasma LPL activity was not lower in APOC1 mice compared with controls, apoC-I was able to dose-dependently inhibit the LPL-mediated lipolysis of [3H]TG-VLDL-mimicking particles in vitro with a 60% efficiency compared with the main endogenous LPL inhibitor apoC-III. Triglycerides lipoprotein lipase Mus musculus
2 Although total postheparin plasma LPL activity was not lower in APOC1 mice compared with controls, apoC-I was able to dose-dependently inhibit the LPL-mediated lipolysis of [3H]TG-VLDL-mimicking particles in vitro with a 60% efficiency compared with the main endogenous LPL inhibitor apoC-III. Triglycerides lipoprotein lipase Mus musculus
3 Therefore, we conclude that apoC-I is a potent inhibitor of LPL-mediated TG-lipolysis. Triglycerides lipoprotein lipase Mus musculus