Title : Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.

Pub. Date : 2005 Mar 15

PMID : 15572591






2 Functional Relationships(s)
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1 Analysis of the TCR-induced signaling cascade showed that imatinib substantially reduced tyrosine phosphorylation of ZAP70 and LAT in response to activation through the TCR. Tyrosine T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens
2 Analysis of the TCR-induced signaling cascade showed that imatinib substantially reduced tyrosine phosphorylation of ZAP70 and LAT in response to activation through the TCR. Tyrosine T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens