Pub. Date : 2004 Nov
PMID : 15570242
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heparin treatment mobilizes TFPI into the circulation and contributes to the anticoagulant effects of heparins. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 2 | Previous studies have demonstrated a selective depletion of intravascular TFPI by unfractionated heparin (UFH) but not by low-molecular-weight heparin (LMWH). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 3 | Previous studies have demonstrated a selective depletion of intravascular TFPI by unfractionated heparin (UFH) but not by low-molecular-weight heparin (LMWH). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 4 | In this study we sought to investigate the time- and dose-dependent relationships between release of TFPI and lipoprotein lipase (LPL) in respons to UFH and LMWH and to investigate whether the selective depletion of TFPI by UFH but not by LMWH is related to differential urinary excretion of TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 5 | Similar dose-dependent mobilization of TFPI and lipoprotein lipase (LPL), another glucosaminoglycan (GAG)-anchored protein of the endothelial membrane, was observed after both subcutaneous and intravenous administration of heparins. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 6 | However, UFH induced a more efficient release of both TFPI and LPL into plasma than did LMWH at equivalent anti-Xa levels, indicating molecular-weight dependence of the release reactions. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 7 | UFH and LMWH treatment reduced renal clearance of TFPI compared with the control regimen. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 8 | Our findings suggest that displacement of TFPI from the endothelial-surface GAG is the main mechanism for TFPI release during heparin treatment in vivo and that differential urinary excretion of TFPI is not the explanation for selective depletion of TFPI during UFH treatment. | Heparin | tissue factor pathway inhibitor | Homo sapiens |