Title : Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis.

Pub. Date : 2004 Dec

PMID : 15569309






3 Functional Relationships(s)
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1 METHODS: Cisplatin (30 mg/kg) was injected intraperitoneally into wild-type and caspase-1-deficient (-/-) C57BL/6 mice. Cisplatin caspase 1 Mus musculus
2 CONCLUSION: These results indicate that caspase-1 contributes to cisplatin-induced ARF and ATN (day 3). Cisplatin caspase 1 Mus musculus
3 Furthermore, caspase-1 affects caspase-3 activation and apoptosis in cisplatin-induced ARF (day 2). Cisplatin caspase 1 Mus musculus