Title : Glucose stimulates the expression and activities of nitric oxide synthases in incubated rat islets: an effect counteracted by GLP-1 through the cyclic AMP/PKA pathway.

Pub. Date : 2005 Feb

PMID : 15558323






2 Functional Relationships(s)
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1 We conclude that the induction of iNOS and the increase in ncNOS activity caused by glucose in rat islets is suppressed by the cyclic AMP/PKA system. Cyclic AMP nitric oxide synthase 2 Rattus norvegicus
2 The inhibition of iNOS expression by the GLP-1/cyclic AMP/PKA pathway might possibly be of therapeutic potential in NO-mediated beta-cell dysfunction and destruction. Cyclic AMP nitric oxide synthase 2 Rattus norvegicus