Title : Effect of lung resistance-related protein on the resistance to cisplatin in human ovarian cancer cell lines.

Pub. Date : 2004 Dec

PMID : 15547764






9 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Effect of lung resistance-related protein on the resistance to cisplatin in human ovarian cancer cell lines. Cisplatin major vault protein Homo sapiens
2 The purpose of this study was to investigate whether LRP is involved in the resistance of ovarian cancer cell lines to cisplatin and its molecular mechanism. Cisplatin major vault protein Homo sapiens
3 The expressions of LRP in A2780/DDP and COC1/DDP cells were higher than those in A2780 and COC1 cells and conferred resistance to cisplatin. Cisplatin major vault protein Homo sapiens
4 Levels of cisplatin accumulating in cells were increased by LRP-specific AsODN and anti-LRP monoclonal antibody. Cisplatin major vault protein Homo sapiens
5 Levels of cisplatin accumulating in cells were increased by LRP-specific AsODN and anti-LRP monoclonal antibody. Cisplatin major vault protein Homo sapiens
6 Isolated nuclei from A2780 and COC1 cells or A2780/DDP and COC1/DDP cells incubated with anti-LRP antibody contained more cisplatin than the nuclei of A2780/DDP and COC1/DDP cells not treated with anti-LRP antibody. Cisplatin major vault protein Homo sapiens
7 Efflux of cisplatin was greater from the nuclei of A2780/DDP and COC1/DDP cells than those of A2780 and COC1 cells, and was inhibited by anti-LRP monoclonal antibody. Cisplatin major vault protein Homo sapiens
8 Thus, LRP was involved in the resistance of ovarian cancer cells to cisplatin and has an important role in the transport of cisplatin both in exocytotic vesicles and between the nucleus and cytoplasm. Cisplatin major vault protein Homo sapiens
9 Thus, LRP was involved in the resistance of ovarian cancer cells to cisplatin and has an important role in the transport of cisplatin both in exocytotic vesicles and between the nucleus and cytoplasm. Cisplatin major vault protein Homo sapiens