Title : 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.

Pub. Date : 2005 Feb

PMID : 15547111






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Co-incubation with pifithrin-alpha (PFT-alpha), a selective p53 inhibitor, restored GADD45, Bcl2, cyclin B1, and p21(WAF1) expression levels and almost completely reversed the growth inhibitory, cell cycle, and apoptotic effects of 5-aza-CR. pifithrin BCL2 apoptosis regulator Homo sapiens