Title : Synthesis and evaluation of a triplex-forming oligonucleotide-pyrrolobenzodiazepine conjugate.

Pub. Date : 2004 Nov-Dec

PMID : 15546183






1 Functional Relationships(s)
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1 To stabilize binding to a polypurine tract in the HER-2/neu promoter, a triplex forming oligonucleotide (TFO) was conjugated to a pyrrolo[1,4]benzodiazepine (PBD), desmethyltomaymycin, and site-specific DNA binding was evaluated. tfo erb-b2 receptor tyrosine kinase 2 Homo sapiens