Title : Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis.

Pub. Date : 2004 Dec

PMID : 15538122






1 Functional Relationships(s)
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1 Because NADPH-oxidase/MPO may oxidize clozapine to highly reactive nitrenium ions, we investigated the role of hereditary polymorphisms in the NADPH oxidase/myeloperoxidase system in agranulocytosis patients who received clozapine (n = 49), ticlopidine (n = 11), and other drugs prior to the event. nitrenium myeloperoxidase Homo sapiens